With a 0.1 nA precision current monitoring and 100% automatic control, the SSX makes high-performance nano-electrospray truly easy to operate.

We had to adjust the mechanical latches and the sealing because this was the first time we coupled an SSX to a Q Fortis MS. Thanks to Kseniya Dryahina, Patrik Španěl, Radim from Pragolab s.r.o., and the team at the J. Heyrovský Institute of Physical Chemistry CAS, this was completed in one day, and we were happily acquiring breath and headspace data on the second day :)

Identifying the best capillary size

The electrospray (ES) emitter is an essential part of a high-res mass spectrometry system. The quality of the data is linked to a reliable ES. Despite its central importance, this little piece of equipment isn’t well known.

LESSON #1: ONE SIZE DOES NOT FIT ALL

Thanks to SuperSESI we can finally see, accurately and in real time, what happens in our lungs after smoking.

Secondary electrospray ionization and tools like Super SESI allow us to safely detect large molecules in the gas phase, with an extremely low LoD.

What if we could detect COVID-19 and other viruses in real-time, in a noninvasive way? No more needles, no more poking in noses, no more waiting!

Converting data to knowledge can be a daunting task because breath samples are complex. This gap has been bridged with high-quality data and advanced metabolomics data analysis techniques.

For this, statistical and biological relevance are essential.

Chapter 12, co-authored by Jiayi Lan, Francisco Blanco Parte, Guillermo Vidal-de-Miguel, and prof. Renato Zenobi, from ETH Zürich and Fossil Ion Technology, shows how SESI greatly enhances breath analysis capabilities.

Congratulations to Jérôme Kaeslin, Renato Zenobi, Jiayi Lan, Tobias Bruderer, Alexander Moeller, Amanda Gisler, and Pablo Sinues for your great contribution to science! We are proud to be at your service.

Guillermo Vidal-de-Miguel, our CEO, explains it in detail! We hope you enjoy it ;)

Analyzing the Volatilome via Secondary Electro-Spray Ionization (SESI): Technical Development and its Application to Breath and Microbial VOCs

Visit our Virtual Booth at ASMS 2020, and arrange a virtual meeting with us.

This paper, published by our colleagues at ETH Zurich, reports the detection of a whole series of ω-oxidation products of unbranched medium-chain fatty acids in exhaled breath (ω-hydroxy alkanoic acids, ω-oxoalkanoic acids, and alkanedioic acids) with carbon chain lengths of 5-15. These metabolites correlated with the ω-oxidation pathway in a study with 146 healthy individuals.

Molecular breath analysis supports altered amino acid metabolism in idiopathic pulmonary fibrosis (IPF).This paper, authored by our colleagues from the University of Zurich, shows that amino acids detected by breath analysis in real-time correlate with ongoing fibrotic processes.

Demo: a SUPER SESI-Orbitrap system will be installed at the SUMS laboratory to show breath analysis in real-time and other samples.

Seminario en la Facultad de Farmacia de Albacete (UCLM): Análisis del volatiloma en tiempo real - Avances técnicos e instrumentales

PMI has decided to bet on a smoke-free future. For this, they have decided to make the required investments in biomedical research and scientific equipment. The goal is to replace cigarettes as soon as possible with smoke-free alternatives.SUPER SESI will help to asses the kinetics of different smoke-free products, and lower the risk of harm caused by smoking.

In the last ten years, we have developed the tools required to analyze dynamic changes in metabolism. A key technical challenge was to detect large and biologically relevant molecules in the gas phase, which allowed for the analysis of respiration metabolites. This article describes and illustrates this new window into the metabolism and the volatilome. With an exclusive look at high ionization efficiency of Secondary Electro-Spray Ionization (SESI) and Super SESI application.

Post-doctoral researcher Kapil Dev Singh (UKBB) presented part of his studies on therapeutic drug monitoring at the MSACL congress. They measured exhaled breath in pediatric patients treated with antiepileptic medication, and compared it with Gold Standard blood test. They identified secondary metabolites of valproic acid (VPA), and were able to predict the serum concentration of total and free VPA in real time in a non-invasive way, using the platform SUPER SESI - Orbitrap.