Biologically relevant metabolites in real time

a non-invasive window into the human metabolism

 
  • Each exhalation carries several thousand metabolites

  • Breath reflects our metabolism in that particular moment

  • WE breathe up to 30,000 times per day

DETECT RELEVANT METABOLITES

 
  • The larger molecules tend to be more specific from a biological standpoint

  • but they have lower volatility. For this reason, they are very diluted in breath

  • Detecting them requires very high performance instrumentation

  • SUPER SESI is optimized to detect low volatility species at minute concentrations

 

Direct, real time analysis

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Despite the advantages of breath analysis, most attempts to identify biomarkers of disease have failed because of confounding variables. By analyzing breath on-line, several sources of cross contamination and confounding variables are eliminated.

Elements required:
- SUPER SESI,
- EXHALION, and
- your Mass Spectrometer

 

real-time drug metabolism

biomarker discovery

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Off-line analysis system (new)

Bringing patients into the lab is not always possible. For these situations, we introduce our bag sampling and de-sampling system.

 

Some strategies to minimize the impact of confounding variables:

  • use inert materials

  • ensure that all samples are stored and analyzed in the same conditions

  • minimize the chemical interaction between the sample and the sampling system

  • minimize handling

  • minimize the storage time.

 
 
 

SCIENTIFIC LITERATURE

 

The field of breath analysis research is very extensive, with several groups working on it. Some areas of interest include:

  • Bio-marker research in Pulmonology & Gastroenterology.

    • Breath comes from the respiratory system, and it is in contact with the oral cavity. It is rich in of lung and gastric metabolites.

    • Some lung problems which could greatly benefit from a breath diagnosis protocol: Pneumonia, TB, COPD, Asthma, Lung Cancer…

  • Bio-markers research of VOCs in blood. The lung exchanges chemical species between blood and breath very efficiently, thus providing access the bloodstream, and the entire body.

  • Pharmaco-kinetics. Breath is a non invasive. SUPER SESI allows for the analysis of multiple exhalations, causing no discomfort.

 
 

Thinking of including breath test in your next clinical study?

check our TIPS TO INCLUDE SUPER SESI IN YOUR BREATH RESEARCH PROTOCOL

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  • A basic breath research plan aimed at the discovery of new breath biomarkers can be categorized as Clinical Study.

  • We have prepared a free guide to help you prepare the corresponding Clinical Study Protocol to include SUPER SESI.