SESI and ESI (Electro-Spary Ionization) have been linked since the initial development of ESI. Fenn and colleagues already noted that gas-phase species in the counterflow gas were also ionized by the spray. Still today, the routine calibration of mass spectral data relies on ubiquitous plasticizes and other contaminants (i.e. polydimethylcyclosiloxanes, phthalates) that are ionized in regular ESI via Secondary Electrospray Ionization mechanisms.
The ETH Zurich (Switzerland) has recently completed the acquisition and installation process of a new SUPER SESI unit for a Thermo Fisher Scientific Orbitrap mass spectrometer, that will help in different fields of the research conducted at this institution related to metabolomic studies.
Rising the humidity level of the gas introduced through the sample line accelerates the charge transfer reaction rate in Secondary Electrospray Ionization (SESI). It is hypothesized that larger clusters transfer their charge more efficiently than smaller clusters or even bare ions.
As you probably already know, current VOC MS analyzers can detect high volatile species, even when they are present in very low concentrations. For instance, in 2009 P. Spanel and D. Smith measured the concentration of ammonia, acetone, methanol, ethanol, and isoprene in human breath using Selected Ion Flow Tube Mass Spectrometry (SIFT-MS)  .
In the equilibrium, both Secondary Electro Spray Ionization (SESI) and Atmospheric Pressure Chemical Ionization (APCI) generate charged water clusters that act as charging agents. What are the differences bewtween these ionization techniques?
The European Organization for Nuclear Research (CERN) has officially reached an agreement with Fossiliontech through a project supported by Ineustar-Pioneers and Promalaga to develop a data processing system tool incorporating CERN algorithms, in order to create a post-processing server that shares the conclusions obtained by all scientists working on breath analysis with SUPER SESI.
Sinues is a pioneer of the SESI technology and established SESI-MS as a technique for breath research. The goal in the granted project is to optimize the therapeutic regimen of pediatric patients to maximize efficacy and minimize side effects. For this the group will develop a mass spectrometry-based breath test.
Universitäts-Kinderspital Zürich is one of the main clinical institutions in Swizerland working on the field of breath analysis. Together with other institutions and research centers in the region, they have shown a strong commitment to innovation …
Everyone knows that researching is not an easy task and generates a huge amount of data. However, despite being valuable not all the data resulting from our researches finally come into existence because it is not included in a published and printed poster, paper, article…
Breath Analysis performed with SUPER SESI is one of the topics of Thursday 22nd November (19.30) Beer for Science talk organised by Uciencia, the Publications and Scientific Dissemination Service of the University of Malaga.
In order to consider biomarkers during drug development processes, they must have been approved directly by the US Food and Drug Administration (FDA) staff or must undergone the FDA's Biomarker Qualification Program (BQP).