Practical Applications of Secondary/ Extractive Electrospray Ionization (SESI): A Versatile Tool for Real‐Time Chemical Analysis

X.Luo, H. Wang, X. Hu, Sa. Gligorovski, X.Liu, P.Sinues

Abstract

SESI and EESI: Two Decades of Real-Time Volatile Analysis
Since their resurgence during the ambient mass spectrometry revolution, secondary electrospray ionization (SESI) and extractive electrospray ionization (EESI) have transformed real-time analysis of gas and aerosol mixtures. Originally discovered in the 1980s, these techniques now underpin a wide range of applications—from drug detection to environmental monitoring and metabolomics. Over the past two decades, the field has seen rapid expansion, thanks in part to technological advances driven by innovators such as Fossiliontech (FIT). This review summarizes key milestones, showcases diverse applications, and outlines emerging opportunities and challenges.

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