Drug Pharmacokinetics Determined by Real-Time Analysis of Mouse Breath

SUPER SESI-HRMS was used to non-invasively and in real-time monitor the pharmacokinetics of ketamine, propofol, and valproic acid, along with their metabolites in mice. This approach allowed for obtaining real-time pharmacokinetic curves without the need to sacrifice the animals, representing a significant advance in terms of animal welfare and time and cost savings.

Guest User 7/28/22 Guest User 7/28/22

How would bio-production look if volatile bio-products of fermentation could be detected in real-time (within seconds) and without sample preparation?

Hendrik Mengers, Martin Zimmermann & Lars M. Blank from Aachen University monitored the volatilome of yeast during growth in a shake flasks bioreactor. Among many more metabolites, they caught the evolution of acetaldehyde and ethanol within seconds.

Guest User 2/12/22 Guest User 2/12/22

The first Super SESI X (SSX) is is fully functional and in service.

With a 0.1 nA precision current monitoring and 100% automatic control, the SSX makes high-performance nano-electrospray truly easy to operate.

We had to adjust the mechanical latches and the sealing because this was the first time we coupled an SSX to a Q Fortis MS. Thanks to Kseniya Dryahina, Patrik Španěl, Radim from Pragolab s.r.o., and the team at the J. Heyrovský Institute of Physical Chemistry CAS, this was completed in one day, and we were happily acquiring breath and headspace data on the second day :)

Guest User 12/27/21 Guest User 12/27/21

Know Your Emitter #1

Identifying the best capillary size

The electrospray (ES) emitter is an essential part of a high-res mass spectrometry system. The quality of the data is linked to a reliable ES. Despite its central importance, this little piece of equipment isn’t well known.

LESSON #1: ONE SIZE DOES NOT FIT ALL

Guest User 12/23/21 Guest User 12/23/21

Monitoring of Exogenous Compound Kinetics in Exhaled Breath

Thanks to SuperSESI we can finally see, accurately and in real time, what happens in our lungs after smoking.

Guest User 11/18/21 Guest User 11/18/21

In-vitro volatilome profiles of lung cancer captured with Super SESI - Orbitrap platform

This work from the Ohio State University shows the potential of the platform SUPER SESI (by Fossiliontech) - Orbitrap (by Thermo Fisher Scientific) on differentiating cancer types and monitoring their treatment.

Guest User 11/12/21 Guest User 11/12/21

Why automate every control of an ion source?

Electrospray provides the best performance, but obtaining a stable signal can be tricky.
The new SUPER SESI-X, designed for the Thermo Orbitrap Exploris series, is fully automatic and is ready to incorporate intelligent control. This source will auto-pilot the electrospray to bring high performance and reliability.

Guest User 9/30/21 Guest User 9/30/21

This is what the offline solution for Super SESI looks like

We have developed this first pilot unit within the PERFECT LIFE project (funded by the European Union). It comprises a gas conditioning unit, a desorber, the Super SESI, the MS, and of course, the cartridges!