K. Fricke, D. M. Baur, K. D. Singh, F. Schmidt, K. Müsch, N. A. Sievi, M. Di Donato, A. Schmick, J. Herth, S. Ulrich, P. Sinues, M. Galovic, M. Kohler
Abstract
Non-Invasive Drug Monitoring Through Exhaled Breath
This study explores exhaled breath as a non-invasive approach for estimating systemic exposure to antiseizure medications. Using Exhalion and Super SESI coupled to a Q Exactive Plus Orbitrap mass spectrometer, SESI-HRMS breath profiles from 117 adults were compared with paired serum measurements.
Breath-derived models showed moderate agreement with serum concentrations for valproic acid, levetiracetam, lamotrigine, and lacosamide. The results support real-time breath metabolomics as a complementary approach for multi-drug exposure monitoring, while further multicenter validation is required before clinical implementation.