Exploring exhaled breath biomarkers for lactose intolerance diagnosis: the Lactobreath pilot study protocol
S. Giannoukos, K. J.e Burton-Pimentel, R. Guillod, G. Vergères, D. Pohl
Abstract
The Lactobreath study explores real-time breath analysis as a novel, non-invasive tool to detect lactose intolerance. In this double-blind trial, 120 participants undergo postprandial testing with lactose or glucose. Using Super SESI-HRMS, the study captures detailed exhalome profiles and correlates them with symptoms, hydrogen levels, gut transit (via ingestible gas capsules), bowel sounds, urine metabolites, and genetic markers. This integrative approach aims to move beyond standard hydrogen breath tests and validate molecular breath signatures as clinical biomarkers for food intolerance.
Trial ID: NCT06177938
Ethics Approval: KEK Zürich (#2023-01639)