J. Pang

SESI-HRMS in Exercise Breathomics

This review highlights saliva, sweat, and exhaled breath as noninvasive matrices for monitoring exercise-related physiology. Among them, exhaled breath stands out for its ability to capture rapid metabolic changes on a second-scale timeframe. The review points to SESI-HRMS as one of the key analytical technologies advancing breathomics from the detection of individual volatile compounds toward real-time, pathway-level metabolic interpretation during exercise. For SESI-based breath analysis, this reinforces its potential as a powerful approach for noninvasive monitoring of substrate use, metabolic dynamics, and physiological responses in sports and exercise science.

R Weber, B Streckenbach, J Kaeslin, L Welti, D Inci, N Perkins, R Zenobi, S Micic, A Möller.
We hypothesized that the breath of children with allergic asthma contains a unique signature of disease specific metabolites. Using secondary electrospray ionization high-resolution mass spectrometry (SESI-HRMS), we aimed to identify relevant VOCs to assess underlying interconnections between biomarkers belonging to common metabolic pathways in the pathophysiology of asthma.