Real-time breath drug metabolic monitoring under stellate ganglion block with lidocaine: a proof-of-concept study
Z. Yin, W. Xiong, K. Zhang, X. Luo, M. Wei, K.D. Singh1,2, U. Frey, X. Li, X. Feng, and P. Sinues
Abstract
Breath metabolomics under lidocaine-SGB
This pilot study provides the first real-time metabolic profiling of lidocaine-based stellate ganglion block (SGB) using high-resolution breath analysis (SESI-HRMS). In 28 participants, more than 300 metabolites were significantly altered after lidocaine injection, including both drug-derived compounds and endogenous metabolites linked to fatty-acid oxidation and amino-acid metabolism. The findings demonstrate that breath metabolomics can simultaneously capture drug metabolism and host physiological responses, while revealing notable inter-individual variability. This work positions breath-based pharmacometabolomics as a promising tool for personalized monitoring and optimization of SGB interventions in clinical practice.