REAL TIME ANALYSIS OF LOW VOLATILITY
MOLECULES IN THE GAS PHASE

WHAT IS SUPER SESI?

 

SUPER SESI is a highly sensitive ion source that harnesses the power of high-resolution mass spectrometry
to enable online ionization of low volatility metabolites. 

 
 

  • SUPERIOR TECHNOLOGY. Built upon Secondary Electro-Spray Ionization (SESI), SUPER SESI helps making real-time analysis of volatile organic carbon compunds (VOCs) a reality today.

  • RELEVANT RESULTS. Due to its focus on low volatility species, SUPER SESI detects larger molecules, more relevant from a biological standpoint.

  • EASY-TO-USE. SUPER SESI is designed under a plug and play philosophy and optimized for high performance commercial mass spectrometers (Thermo and Sciex).

  • EASY-TO-CLEAN. SUPER SESI automates some cleaning procedures, and facilitates deep cleaning to keep contamination in check.

 
 

WHO IS USING SUPER SESI?

Scientists and researchers worldwide are leveraging SUPER SESI in different disciplines and fields and with distinct applications and purposes.

 
SCIENTISTS SUPPORTING SUPER SESI
Rosaria Orlandi
Rosaria Orlandi

Instituto dei Tumori di Milano
(Italy)

Manager of the biology and health research group at the Unit for Molecular Targets, Department of Experimental Oncology and Molecular MedicineThe following is placeholder Fondacione IRCCS Instituto Nazionale Tumori, Milano.

Orlandi is using SUPER SESI for the research of breath collected in Milar containers for the identification of cancer bio-markers. Her work is allowing us to better understand the specific requirements of this process, and it is at the back of our Off-line Replicator.

Alfredo J. Ibañez
Alfredo J. Ibañez

PUCP
(Peru)

Leader of the Max Planck - PUCP partner research group, and Director of the core facility for omics research and applied biotechnology (ICOBA) at the Pontificia Universidad Católica del Perú (PUCP).

His research interests, are the development of biological analysis using mass spectrometry, and applied research in the field of biology (in particular metabolomics and proteomics).

Malcolm Kohler
Malcolm Kohler

University of Zürich
(Switzerland)

Chair of Respiratory Medicine at the University of Zurich and Clinical Director of the Department of Pulmonology of the University Hospital of Zurich.

Kohler initiated and directs a PhD program in clinical science at the University of Zurich. His research focuses on the pathophysiology and treatment of obstructive sleep apnoea and other chronic respiratory disorders.

Tobias Bruderer
Tobias Bruderer

ETH Zürich
(Switzerland)

PhD in Pharmaceutical Sciences in Analytical Chemistry (University of Geneva), with focus on advanced mass spectrometry in bioanalysis and metabolomics.

Bruderer has been an early adopter of SUPER SESI, and has participated in the development of the SUPER SESI for Sciex. Many of the improvements implemented in the new generation of SUPER SESI have been implemented in response to the requirements identified by TB.

Alexander Möller
Alexander Möller

Zürich Kinderspital
(Switzerland)

PD Dr. med., and  Chief Pulmonology Physician at the Children University Hospital of Zurich (Zurich Kinderspital).

Möller provided extremely valuable insights on the use of breath research in the clinical environment, and the dynamics of the lung, which are essential when the lungs and the SUPER SESI operate as a coupled fluid mechanical system.

Pablo ML.Sinues
Pablo ML.Sinues

University of Basel
(Switzerland)

Assistant Professor at the University of Basel (Department of Biomedical Engineering), and principal investigator of the Research Network Zurich Exhalomics

Sinues is a pioneer of SESI technology. He established the fundamental mechanistic studies that today allow us to understand SESI ionization mechanism. More importantly, Sinues pioneered and established SESI-MS as a technique for breath research. His proactive role in the definition of SUPER SESI and its requirements has been essential.

 
 

SOLVE THE TIME DIMENSION OF METABOLOMIC STUDIES

WHAT IS SUPER SESI FOR?

Secondary Electro-Spray Ionization (SESI) technique and hence SUPER SESI can help researchers and scientists with online analysis of breath and other applications requiring a real-time analysis of metabolites in the gas phase.

 
 

BREATH ANALYSIS

We have developed a comprehensive solution for molecular analysis of breath with Mass Spectrometry (SESI-MS). It is composed of:

  • SUPER SESI. Highly efficient and sensitive ion source compatible with Thermo and Sciex Mass Spectrometers.

  • EXHALION capnography system. It collects the flow exhaled by a person trough a disposable spirometer antibacterial filter, and measures the exhaled flow and CO2 concetration.

  • ARIADNE software. It is a post-processing service specifically designed for SUPER SESI data. It provides an intelligent analysis of the data, and automatically monitors the background levels.

 
 
 
 

OTHER APPLICATIONS

 
 

wHY SUPER SESI?

up to 240,000

RESOLUTION
CAPACITY

1 sec

TIME
resolution

UP TO 2,500

SPECIES PER
EXHALATION

 
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HIGH RESOLUTION

The ionization efficiency of SUPER SESI harnesses the power of high performance mass spectrometry.

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NO SAMPLE-Handling

Gas sample is introduced directly, reducing the confounding variables risk and providing reliable results.

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immediate response

Coupled to a mass spectrometer SUPER SESI performs real-time analysis, enabling metabolic kinetic studies.

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BIOLOGICAL RELEVANCE

Heavy molecules are relevant. SUPER SESI is designed to ionize low volatility molecules minimizing fragmentation.