Electrospray Ionization

Proteomics, Breath Analysis and Volatilomics.

Bio-analytical instrument development and electro-fluidic mechanics expertise to make the finest ionization systems at the service of scientists.

DISCOVER OUR PRODUCTS

SUPER SESI-X is optimized for the Thermo Exploris, Tribrid and TSQ MS series. Detection of biologically relevant vapor and nano-aerosol ionization in real-time.

SUPER SESI-QE is optimized for LTQ, Exactive, and Q-Exactive Orbitrap series. Detection of biologically relevant vapor and nano-aerosol ionization in real-time.

EXHALION. Breath analysis guide. Compatible with standard spirometry antibacterial filters, provides CO2 and flow measurements, and guides the exhalation maneuver.

nano-electrospray (n-ESI) Emitters, the Sharp Singularity. Stable and repeatable nano electro-spray with precision micro-machined, fully traceable, and elongated emitters. ID from 10 μm to 50 μm.

we re-engineered the column-emitter block to improve data reproducibility through geometric reproducibility

BREATH ANALYSIS

Instantaneous and on-invasive. Breath biomarkers carry information on the state of human health. Their study will accelerate the prognosis and early diagnosis of disease.

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Animal VOC´s

SUPER SESI-HRMS enables non-invasive, real-time analysis of animal-emitted VOCs, offering insights into their health and physiological conditions

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Food & Aroma

SUPER SESI-HRMS is a non-destructive, real-time method for assessing food safety and quality without sample preparation, useful in identifying product origin and detecting contaminated food to ensure public health

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Microbiology

Analyzing volatile organic compounds (VOCs) in cell culture headspace has multifaceted applications in microbiology, including organism identification, monitoring culture growth, targeting metabolic pathways, and studying responses to various stimuli.

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VOLATILOMICS

Resolving the time dimension of metabolomic studies. Monitoring naturally emitted volatile compounds facilitates real time monitoring of metabolic processes.

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PROTEOMICS

nano-electrospray is used in proteomic because of its high performance. Our emitters are designed based on first principles, and made with attention to details so that the spray just works.

Go to n-ESI for proteomics

Electrospray Academy

Watch our videos to learn about electrospray related topics in a didactic way. And if you don’t want to miss new releases, you can also Subscribe to our YouTube channel ;) Playing with ions

Go to Electrospray Academy

Customer reviews:

n-ESI emitters and Dragonfly self-pack columns:

BC Cancer Research Centre (Canada) - Selfpack Dragonfly nano-Column with LOTUS emitter

“Overall, we are very happy with the performance of the LOTUS (Dragonfly) columns. They pack very easily and are extremely stable. This latter aspect is probably the best part about them, the tip performance never seems to degrade. Usually with self-pulled emitters, the tip performance will degrade after 100 injections or so in my experience. The first column I packed in the LOTUS emitter column lasted for over 1000 injections without a drop in performance (and this wasn't continuous usage either, it was uninstalled and reinstalled many times). The only reason I stopped using that one actually was it looked like the capillary around the column-emitter junction was starting to become a bit worn out and I was worried it was going to break, but the tip itself was still fine”.

Acoustica Bio (USA) - LOTUS emitters ref. 50-05 and 30-05.

“The emitters worked great! Congrats on your products – they are very well made.“

The Kennedy Group - University of Michigan (USA) - 20 μm ID with a flow rate of 250-750 nL/min.

“We use The Sharp Singularity nano-ESI emitters with our Q-Tof Premier Mass Spectrometer from Waters. They are working really well for us. The spray stability we can reach with them is better than with other brands we have tried in the past!"

Universitätsspital Zürich, USZ (Switzerland) - 20 μm ID

"Our group has been using FIT's products since many years ago, and we're very happy with them! The nano-ESI emitters The Sharp Singularity are working great with our Orbitraps. The first time we tried them we had some issues, but after a videocall with Guillermo (FIT's CTO) he gave us some tips and everything was solved"

Max-Planck-Institut für molekulare Zellbiologie u. Genetik (Germany) - 20 μm ID with a flow rate of 400-500 nL/min.

“We are very happy with "The Sharp Singularity" nano-ESI emitters. We work in proteomics, and we use them with all the Orbitraps in the lab. We have no bad words about them! They are very robust.”

Department of Infectious Diseases & Immunology - University of Florida (USA) - 20 μm ID with a flow rate of 180-300 nL/min.

"We have been using them with our Q-tof, and we are very happy with them. We had to get used to them because we were using pulled emitters before, but after using them for some time everything worked really well!"

Fondazione IRCCS - Istituto Nazionale dei Tumori (Italy) - 20 μm ID

"We are using the nano-ESI emitters The Sharp Singularity in our latest project and they are working very well. We use them 5 days a week, 5 hours per day, and the results are being very good! They seem cleaner than the New Objective ones we were using before"

National Research Council Canada (Canada) - 30 μm ID

"FIT's nano-ESI emitters are working very well for our experiments!"

Uniwersytet Gdański (Poland) - 10 μm ID with a flow rate of 300 nL/min.

“These nano-ESI emitters are working great for our research in peptidomics. We use them with our Orbitrap Exploris 480, and we are very satisfied with them.”

Super SESI:

Dr. Prof. Patrik Španěl‬ - J. Heyrovsky Institute of Physical Chemistry of the CAS, Prague, Czech Republic

“The SSX ion source is surely a masterpiece of state of the art engineering. Full understanding of the ion chemistry occurring between the ESI generated ions and VOC molecules inside will be an interesting challenge to tackle.”

Prof. Dr. med. Malcolm Kohler - University Hospital Zurich (USZ), Switzerland.

“We observed significant changes in glyoxylate and dicarboxylate, tricarboxylic acid cycle (TCA), and tryptophan metabolic pathways. Our findings suggest that continuous monitoring of metabolite shifts from exhaled air should focus on monitoring platforms dedicated to volatile and slightly volatile metabolites”

Dr. Prof. Pablo Sinues - University Children’s Hospital Basel, University of Basel, Switzerland

“We use SESI-HRMS to sense exhaled molecules at minute concentrations. Since the analysis requires no sample-preparation or manipulation, the diagnostic result can be obtained nearly in real-time. This technology is especially well suited for children due to its non-invasive nature”

Dr. Prof. Jangjiang Zhu - The Ohio State University, Ohio, USA.

“Our results suggested that the optimized SESI-HRMS method can be suitable forthe analysis of VFAs from gut microbes in a rapid, sensitive, and non-invasive manner.”

Dr. Prof. Renato Zenobi - ETH Zurich, Switzerland

“When SESI is combined with state-of-the-art mass spectrometers, low limits of detection (pptv) are achievable without any sample pre-concentration. We exploit this feature in our lab in a number of projects which require fast mass spectrometric analysis of vapors at trace concentrations.”

Dr. Prof. Xue Li - Jinan University, Guangzhou, China.

“IAV infection induces a cascade of metabolite alterations, some of which are excreted via the skin and breath to the ambient air. Such IAV-induced odor traits could be captured by SESI-HRMS by simply dragging the air surrounding the infected mice into the analyzer. The process is non-invasive and rapid, as it requires no sample manipulation.”