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How Soft Is Secondary Electrospray Ionization?

Jérôme Kaeslin, Cedric Wüthrich, Stamatios Giannoukos, and Renato Zenobi

Secondary electrospray ionization (SESI) is a soft ionization method, which is important to avoid interference from in-source fragments and to simplify compound annotation. In this work, it is shown that SESI is softer than electrospray ionization (ESI), and therefore, SESI indeed qualifies as a soft ionization technique. However…

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Technology Guillermo Vidal Technology Guillermo Vidal

Secondary Electrospray Ionization of Complex Vapor Mixtures. Theoretical and Experimental Approach

G. Vidal-de-Miguel, A. Herrero

In secondary electrospray ionization (SESI) systems, gaseous analytes exposed to an electrospray plume become ionized after charge is transferred from the charging electrosprayed particles (the charging agent) to the vapor species. Currently available SESI models are valid for simplified systems having only one type of electrosprayed species …

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