Asthma in one breath: metabolic signatures for allergic asthma in children by real-time breath analysis

R Weber, B Streckenbach, J Kaeslin, L Welti, D Inci, N Perkins, R Zenobi, S Micic, A Möller.
We hypothesized that the breath of children with allergic asthma contains a unique signature of disease specific metabolites. Using secondary electrospray ionization high-resolution mass spectrometry (SESI-HRMS), we aimed to identify relevant VOCs to assess underlying interconnections between biomarkers belonging to common metabolic pathways in the pathophysiology of asthma.