Z. Yin, K. D. Singh, Z. Tang, M. Richard, J. Zeng, U. Frey, P. Sinues, X. Li

Real-Time Metabolic Tracing Through Breath

This proof-of-concept study explores the use of SESI-HRMS for noninvasive, real-time metabolic isotopic tracing through exhaled breath after deuterated water ingestion. By monitoring deuterium incorporation in breath metabolites, the approach enables dynamic tracking of metabolic responses across fasting and postprandial states. The study revealed distinct labeling patterns associated with short-chain fatty acids, energy metabolism, and host-microbial metabolic activity, demonstrating the potential of breath-based SESI-HRMS as a powerful tool for metabolic phenotyping, nutritional studies, and future clinical research.

S. Giannoukos, D. Raptopoulos, M. Konstantopoulou

Monitoring Insect Pheromones in Real Time

This study explores the use of SESI-HRMS and portable membrane inlet mass spectrometry for the rapid detection and monitoring of insect sex pheromones. By measuring pheromone levels in the gas phase, these technologies can support more precise pest management strategies, helping verify pheromone coverage, identify gaps, and optimize reapplication in mating disruption programs. The work demonstrates sensitive detection from low ppt to low ppb levels, fast response times, and successful identification of key pheromone components in real Plutella xylostella headspace samples, highlighting a promising path toward real-time and field-deployable pheromone monitoring.