2019

Standardization procedures for real-time breath analysis by secondary electrospray ionization high-resolution mass spectrometry

Kapil Dev Singh, Georgi Tancev, Fabienne Decrue, Jakob Usemann, Rhea Appenzeller, Pedro Barreiro, Gabriel Jaumà, Miriam Macia Santiago, Guillermo Vidal de Miguel, Urs Frey, Pablo ML Sinues

Despite the attractiveness of breath analysis as a non-invasive means to retrieve relevant metabolic information, its introduction into routine clinical practice remains a challenge.

Molecular breath analysis supports altered amino acid metabolism in idiopathic pulmonary fibrosis

Molecular breath analysis supports altered amino acid metabolism in idiopathic pulmonary fibrosis

Martin Thomas Gaugg, Anna Engler, Lukas Bregy, Yvonne Nussbaumer-Ochsner, Lara Eiffert, Tobias Bruderer, Renato Zenobi, Pablo ML Sinues and Malcolm Kohler.

Background
Collagen-related amino acids are significantly increased in exhaled breath of idiopathic pulmonary fibrosis (IPF) patients compared with healthy controls. The detection of these amino acids using real-time breath analysis results in a good discrimination between the groups, indicating the possibility for a rapid, non-invasive screening for IPF.

Real-time breath analysis reveals specific metabolic signatures of COPD exacerbations

Real-time breath analysis reveals specific metabolic signatures of COPD exacerbations

Martin Thomas Gaugg, Yvonne Nussbaumer-Ochsner, Lukas Bregy, Anna Engler, Nina Stebler, Thomas Gaisl, Tobias Bruderer, Nora Nowak, Pablo ML Sinues, Renato Zenobi and Malcolm Kohler.

Background
Exacerbations of chronic obstructive pulmonary disease (COPD) are defined by acute worsening of respiratory symptoms leading to a change in therapy.