2012

Monitoring Diurnal Changes in Exhaled Human Breath

Monitoring Diurnal Changes in Exhaled Human Breath

P. M-L Sinues, M. Kohler and R. Zenobi

The development of noninvasive analytical techniques is of interest to the field of chronobiology, in order to reveal the human metabolome that seems to show temporal patterns and to predict internal body time. We report on the real-time mass spectrometric analysis of human breath as a potential method to be used in this field.

High mass resolution breath analysis using secondary electrospray ionization mass spectrometry assisted by an ion funnel

High mass resolution breath analysis using secondary electrospray ionization mass spectrometry assisted by an ion funnel

L. Meier, C. Berchtold, S. Schmid and R. Zenobi

In this study, we used secondary electrospray ionization mass spectrometry assisted by an ion funnel (IF) operating at ambient pressure to find compounds in the mass range of 100–500 m/z in online breath fingerprinting experiments. In low-resolution experiments conducted on an ion trap instrument, we found that pyridin is present in breath of individuals long after drinking coffee …

Low-Sample Flow Secondary Electrospray Ionization: Improving Vapor Ionization Efficiency

Low-Sample Flow Secondary Electrospray Ionization: Improving Vapor Ionization Efficiency

G. Vidal-de-Miguel, M. Macía, P. Pinacho, and J. Blanco

In secondary electrospray ionization (SESI) systems, gaseous analytes exposed to an elecrospray plume become ionized after charge is transferred from the charging electrosprayed particles to the sample species. Current SESI systems have shown a certain potential. However, their ionization efficiency is limited by …

Secondary Electrospray Ionization of Complex Vapor Mixtures. Theoretical and Experimental Approach

Secondary Electrospray Ionization of Complex Vapor Mixtures. Theoretical and Experimental Approach

G. Vidal-de-Miguel, A. Herrero

In secondary electrospray ionization (SESI) systems, gaseous analytes exposed to an electrospray plume become ionized after charge is transferred from the charging electrosprayed particles (the charging agent) to the vapor species. Currently available SESI models are valid for simplified systems having only one type of electrosprayed species …

Sensitive detection of drug vapors using an ion funnel interface for secondary electrospray ionization mass spectrometry

Sensitive detection of drug vapors using an ion funnel interface for secondary electrospray ionization mass spectrometry

L. Meier, C. Berchtold, S. Schmid and R. Zenobi

In this study, we use an ion funnel (IF) at ambient pressure to enhance the sensitivity of secondary electrospray ionization (SESI). Atenolol, salbutamol and cocaine as test compounds are delivered to the SESI interface in the gas phase and are charged with three nano electrosprays …