How SUPER SESI can help to identify biomarkers of lung damage?

Molecular breath analysis supports altered amino acid metabolism in idiopathic pulmonary fibrosis (IPF). This paper, authored by our colleagues from the University of Zurich, shows that amino acids detected by breath analysis in real-time correlate with ongoing fibrotic processes.

IPF is histopathologically characterized by a heterogeneous structure, in which areas with fibrosis alternate with areas of normal parenchyma that produce an excess deposition of extracellular matrix components, including collagen and elastin. The amino acids proline, 4-hydroxyproline, valine, alanine, leucine, and isoleucine are some of the principal components of collagen and elastin, and they are overexpressed in fibrotic tissues.

This case-control study, with 21 IPF patients and 21 controls, shows that collagen and elastin amino acids can be detected in the breath. They were overexpressed (p. value < 0,05) in the breath of IPF patients.  
Correlation analysis with other physiological parameters revealed that amino acid breath levels in IPF patients were largely independent of lung function parameters commonly used to stage IPF.

These results suggest that breath amino acid analysis can be used to monitor ongoing fibrotic damages. We think that the same approach can be used to identify biomarkers to diagnose and monitor COVID-19 pneumonia.

There is a long way to go. The good thing: there are many open grants for researches addressing this problem.

To find more papers related to breathing analysis, click here: https://www.fossiliontech.com/scientific-resources