The 72nd Conference on Mass Spectrometry and Allied Topics - ASMS 2024 will take place in Anaheim (California- USA), and we are attending as exhibitors!

We are looking forward to meeting you at booth 253 to discuss the newest topics of Mass Spectrometry.

We are glad to announce that we will be at the next IABR Breath Summit 2024 Conference in Indianapolis, USA!

Breath analysis is a rapidly evolving field thanks to the continuous improvement of analytical instruments and sensor technologies, which are both supported by sophisticated data analysis techniques to reach the goal of completely non-invasive personal monitoring of health conditions and diagnosis of diseases.

We will be there discussing the latest breath-related research, and looking forward to meeting the Breath Research community again! Don't miss it!

Dendritic cells (DCs) actively sample and present antigen to cells of the adaptive immune system and are thus vital for successful immune control and memory formation. Immune cell metabolism and function are tightly interlinked, and a better understanding of this interaction offers potential to develop immunomodulatory strategies. However, current approaches for assessing the immune cell metabolome are often limited by endpoint measurements, may involve laborious sample preparation, and may lack unbiased, temporal resolution of the metabolome. In this study, we present a novel setup coupled to a secondary electrospray ionization-high resolution mass spectrometric (SESIHRMS) platform allowing headspace analysis of immature and activated DCs in real-time with minimal sample preparation and intervention, with high technical reproducibility and potential for automation.

Improving the diagnosis and management of pediatric asthma is necessary. Breath analysis can help by assessing altered metabolism and disease-associated processes in a non-invasive manner. This study aimed to identify exhaled metabolic signatures using SUPER SESI - HRMS that can distinguish children with allergic asthma from healthy controls.

This application note highlights the potential of breath analysis in providing valuable insights into the exposure of lungs and the absorption of molecules directly into the bloodstream. The SUPER SESI - QExactive HF -EXHALION system was utilized for breath sample analysis, which recorded a volunteer's breath for 20 minutes after smoking a cigarette. The study captured insights into the kinetics of tobacco metabolites. This approach underscores the capability of breath analysis to provide real-time and valuable data on substance metabolism and exposure. It showcases a significant step forward in non-invasive diagnostic methodologies.

This study explores breath analysis as a tool for therapeutic drug monitoring (TDM) in clinical settings, focusing on valproic acid (VPA) in epilepsy treatment. It contrasts real-time and off-line mass spectrometry methods for analyzing exhaled compounds associated with VPA. Real-time analysis involves direct exhalation into a mass spectrometer, while off-line analysis uses a gas collection device.

Fossiliontech will be at the BMSS Ambient Ionization event on February 1, 2024, at ThinkTank, Birmingham.

We are looking forward to meeting you there. Join us to discover the latest in mass spectrometry and our electrospray ionization technology.

Early detection of pathogenic bacteria is needed for rapid diagnostics allowing adequate and timely treatment of infections. In this study, we show that secondary electrospray ionization–high resolution mass spectrometry (SESI-HRMS) can be used as a diagnostic tool for rapid detection of bacterial infections as a supportive system for current state-of-the-art diagnostics.

We are thrilled to announce a fantastic job opening at Diagnose Early (www.diagnoseearly.com), a pioneer in advanced technological research. Thanks to recent strategic investments, including the acquisition of several state-of-the-art SUPER SESI - Orbitrap breath analysis machines, DE is at the forefront of biomarker identification research.

www.fossiliontech

In this study, SUPER SESI-Orbitrap MS was used to analyze the time-resolved gas-phase volatile organic compounds (VOCs) of garlic, ramsons, and onion.

The aim of this study was to address the difficulties of characterizing heat-labile sulfur molecules from various Allium spp. In this, we will delve into the analytical method SUPER SESI-HRMS used in this study and its applications in the analysis of volatile compounds in garlic, onion, and ramsons.

SUPER SESI-HRMS was used to non-invasively and in real-time monitor the pharmacokinetics of ketamine, propofol, and valproic acid, along with their metabolites in mice. This approach allowed for obtaining real-time pharmacokinetic curves without the need to sacrifice the animals, representing a significant advance in terms of animal welfare and time and cost savings. 

A couple of weeks ago, my colleague Jamil from Fossiliontech attended the Single Cell Proteomics meeting (ESCP, Vienna 2023) and I want to share his notes with you.

I hope this summary will be useful for you :)

Single Cell Analysis: Why?

This technique is essential for understanding cell variability and how it can be applied in diagnostics, personalized therapies, and medical advances.

What technical Challenges need to be addressed?:

A few days ago, we attended a demonstration organized by FossilionTech in the laboratories of Thermo Fisher Scientific in Paris. The performance of the SUPER SESI X-Orbitrap Exploris 120 in the in vitro and in vivo analysis of volatile organic compounds (VOCs) present in food was showcased. The primary goal of this event was to demonstrate the ability of SUPER SESI X-ORBITRAP MS to detect and monitor Volatile Organic Compounds (VOCs) in food, emphasizing the importance of incorporating this technology into food production processes for a deeper understanding of the aromas and flavors of food. Additionally, it highlights the significant improvements in food safety that can be achieved through the adoption of this technology.

To start the new year, our CEO Guillermo Vidal will participate in the MS Winter-Summer School in Funchal, Madeira as invited speaker!

Guillermo’s talk will be on the 9th of January as part of the Single Cell proteomics, ultra-sensitive mass spectrometry session:
Revisiting the fundamentals of Electrospray ionization, from art to technology. 

Please join us on J-n-M in person or online! https://jnm-2023.mozellosite.com/

This year, our CEO Guillermo Vidal will attend the ERS congress in Barcelona!
It will be an opportunity to discuss and present progress in Breath Analysis with Super SESI - HRMS.

If you want to have a meeting with him, contact us.

We will be presenting it at the https://www.imsc2022.com/ in Maastricht, from 27th August to 2nd September.
Visit our stand number 13 to know more!
We will also be there discussing the proteomics and VOCs-related research, and looking forward to meeting the volatilomics and proteomics community again! Don't miss it!

Hendrik Mengers, Martin Zimmermann & Lars M. Blank from Aachen University monitored the volatilome of yeast during growth in a shake flasks bioreactor. Among many more metabolites, they caught the evolution of acetaldehyde and ethanol within seconds.

We are glad to announce that we will be Silver Sponsors in the next IMSC 2022 Conference in Maastricht (The Netherlands)!

We are looking forward to meeting the volatilomics and proteomics community! Don't miss it!

We are glad to announce that we will be Silver Sponsors at the next Metabolomics 2022 conference in Valencia, Spain!

We will be there discussing the latest volatilomics and breath-related research, and looking forward to meeting the metabolomics community! Don't miss it!

The new LOTUS emitters improve protein ID and reproducibility with a hydrophobic coating that stabilizes the meniscus.
This application note shows how to extend the lifespan of your LOTUS emitters.