breath analysis

Real-time breath analysis reveals specific metabolic signatures of COPD exacerbations

Real-time breath analysis reveals specific metabolic signatures of COPD exacerbations

Martin Thomas Gaugg, Yvonne Nussbaumer-Ochsner, Lukas Bregy, Malcolm Kohler, Anna Engler, Nina Steblr, Thomas Gaisl, Tobias Bruderer, Nora Nowak, Pablo ML Sinues, Renato Zenobi.

Background
Exacerbations of chronic obstructive pulmonary disease (COPD) are defined by acute worsening of respiratory symptoms leading to a change in therapy.

Identification of Relatively High Molecular Weight Compounds in Human Breath Using Secondary Nano Electrospray Ionization Ultrahigh Resolution Mass Spectrometry

HUANG Lei, LI Xue, XU Meng, HUANG Zhengxu, ZHOU Zhen

Human breath contains thousands of volatile organic compounds (VOCs), which would be potentially helpful for studying disease diagnosis and environmental exposure. However, owing to limitations in current analytical methods, only the compounds with molecular weights <300 have been widely reported in exhaled human breath.

Direct human breath analysis by secondary nano-electrospray ionization ultrahigh-resolution mass spectrometry: Importance of high mass resolution and mass accuracy

Xue Li, Lei Huang, Hui Zhu and Zhen Zhou.

RATIONALE: Direct mass spectrometry (MS)-based methods make it possible to monitor the molecular compositions of hundreds of volatile organic compounds (VOCs) in exhaled human breath in real time. Mass resolution and mass accuracy play important roles for direct MS analysis, especially for the low-concentration isobaric compounds in non-target research.