PLoS ONE

Circadian Variation of the Human Metabolome Captured by Real-Time Breath Analysis

Circadian Variation of the Human Metabolome Captured by Real-Time Breath Analysis

P. M-L Sinues, L. Tarokh, Xue Li, M. Kohler, S. A. Brown, R. Zenobi, R. Dallmann

Circadian clocks play a significant role in the correct timing of physiological metabolism, and clock disruption might lead to pathological changes of metabolism. One interesting method to assess the current state of metabolism is metabolomics. Metabolomics tries to capture the entirety of small molecules, i.e. the building blocks of metabolism, in a given matrix …

Human Breath Analysis May Support the Existence of Individual Metabolic Phenotypes

Human Breath Analysis May Support the Existence of Individual Metabolic Phenotypes

P. M.-L. Sinues, M. Kohler, R. Zenobi

The metabolic phenotype varies widely due to external factors such as diet and gut microbiome composition, among others. Urine metabolite profiling studies have suggested that there are highly individual phenotypes that persist over extended periods of time. This hypothesis was tested by analyzing the exhaled breath of a group of subjects during nine days by mass spectrometry.