Joint Congress CHEST-SGC

SESI-MS feasibility study with infants and young children for early detection of cystic fibrosis inflammation and infection

SESI-MS feasibility study with infants and young children for early detection of cystic fibrosis inflammation and infection

T. Bruderer, A. Baghdasaryan, J. Wyler, M. Kohler, R. Zenobi, A. Möller

Early and often subclinical pulmonary infection and pronounced neutrophilic inflammation are major contributors to CF-related morbidity. There is a causal relationship between high airway neutrophil elastase activity and the development of bronchiectasis. Early detection of disease and disease-associated complications is crucial for implementing timely therapeutic measures …

Targeted on-line breath analysis discriminates COPD patients vs. healthy controls and subjects suffering from asthma

Targeted on-line breath analysis discriminates COPD patients vs. healthy controls and subjects suffering from asthma

Y. Nussbaumer-Ochsner, M.T. Gaugg, L. Bregy, A. Engler, S. A. Sophie, T. Gaisl, P. M-L Sinues, M. Kohler, R. Zenobi

Recently we found markers in exhaled breath discriminating patients with chronic obstructive pulmonary disease (COPD) from healthy controls using real-time mass spectrometry. The aim of this study was to validate the previously found disease specific metabolic profile of COPD in an independent cohort of patients suffering from chronic obstructive lung disease …

Exhaled breath analysis by real-time Mass spectrometry in patients with pulmonary fibrosis

Exhaled breath analysis by real-time Mass spectrometry in patients with pulmonary fibrosis

P. M-L Sinues, Y. Nussbaumer Ochsner, M.T. Gaugg, L. Bregy, A. Engler, R. Zenobi, M. Kohler.

Idiopathic pulmonary fibrosis (IPF) is recognized as a distinct clinical disorder, however, the diagnosis method remains elusive. Metabolic profiling of biopsied tissue specimens has shown promise to gain insights into IPF pathogenesis. In view of this, the authors hypothesized that the analysis of exhaled metabolites may also provide further insights.

On-line breath analysis with secondary electrospray ionization discriminates between COPD patients with and without frequent exacerbations

On-line breath analysis with secondary electrospray ionization discriminates between COPD patients with and without frequent exacerbations

M. T. Gaugg, Y. Nussbaumer-Ochsner, L. Bregy, A. Engler, N. Stebler, T. BrudererP. M-L Sinues, R. Zenobi, M. Kohler

The authors successfully identified metabolic patterns in exhaled breath, which discriminate COPD patients with and without frequent exacerbations. They propose that their findings correlate with the increased oxidative stress caused by elevated nitric oxide production in response to the pulmonary inflammation.