Transversal Modulation Ion Mobility Spectrometry (TM-IMS)
Ion mobility with a continuous output of ions
IMS is used to analyze isomeric species. TM-IMS provides a continuous output of selected ions. In contrast with traditional Drift tube Ion Mobility Spectrometers (DT-IMS), TM-IMS is the equivalent in ion mobility to the quadrupole mass selector in ion mass.
The TM-IMS technology was invented and developed by FIT's co-founder G. Vidal-de-Miguel. FIT hols the patent rights on this technology, and it is working on its development.
TM-IMS is not a mature technology yet, but its unique features make it very desirable as an add-on IMS system to be coupled with High Resolution Mass Spectrometers, which have a relatively slow time response.
The TM-IMS was tested at the demo lab of Thermo Fisher Scientific in Bremen. It was coupled with an Orbitrap, and we were able to easily obtain IMS-MS data for several samples with unprecedented accuracy. This was a very important milestone for us, our goal is to develop and provide a reliable IMS solution for Orbitrap users.
Principle of operation
TM-IMS combines an axial and steady electric field, and a transversal and oscillating field. Only the ions for which the time of residence within the TM-IMS equates with the period of the oscillating fields, are focused and outputted. By setting the frequency of the oscillating field, the TM-IMS selects which mobility is transferred