SESI and ESI (Electro-Spary Ionization) have been linked since the initial development of ESI. Fenn and colleagues already noted that gas-phase species in the counterflow gas were also ionized by the spray. Still today, the routine calibration of mass spectral data relies on ubiquitous plasticizes and other contaminants (i.e. polydimethylcyclosiloxanes, phthalates) that are ionized in regular ESI via Secondary Electrospray Ionization mechanisms.
As you probably already know, current VOC MS analyzers can detect high volatile species, even when they are present in very low concentrations. For instance, in 2009 P. Spanel and D. Smith measured the concentration of ammonia, acetone, methanol, ethanol, and isoprene in human breath using Selected Ion Flow Tube Mass Spectrometry (SIFT-MS)  .
Everyone knows that researching is not an easy task and generates a huge amount of data. However, despite being valuable not all the data resulting from our researches finally come into existence because it is not included in a published and printed poster, paper, article…
Secondary Electro-Spray Ionization (SESI) uses a nano-electrospray that produces a cloud of charging ions. These ions ionize the vapor molecules that are in contact with the cloud.