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super-SESI Jamil Khirbek super-SESI Jamil Khirbek

Online breath analysis with SUPER SESI - HRMS for metabolic signatures in children with allergic asthma

Improving the diagnosis and management of pediatric asthma is necessary. Breath analysis can help by assessing altered metabolism and disease-associated processes in a non-invasive manner. This study aimed to identify exhaled metabolic signatures using SUPER SESI - HRMS that can distinguish children with allergic asthma from healthy controls.

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super-SESI Jamil Khirbek super-SESI Jamil Khirbek

Monitoring kinetics of tobacco metabolites by breath analysis

This application note highlights the potential of breath analysis in providing valuable insights into the exposure of lungs and the absorption of molecules directly into the bloodstream. The SUPER SESI - QExactive HF -EXHALION system was utilized for breath sample analysis, which recorded a volunteer's breath for 20 minutes after smoking a cigarette. The study captured insights into the kinetics of tobacco metabolites. This approach underscores the capability of breath analysis to provide real-time and valuable data on substance metabolism and exposure. It showcases a significant step forward in non-invasive diagnostic methodologies.

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super-SESI Jamil Khirbek super-SESI Jamil Khirbek

Prediction of systemic free and total valproic acid by off-line analysis of exhaled breath in epileptic children and adolescents

This study explores breath analysis as a tool for therapeutic drug monitoring (TDM) in clinical settings, focusing on valproic acid (VPA) in epilepsy treatment. It contrasts real-time and off-line mass spectrometry methods for analyzing exhaled compounds associated with VPA. Real-time analysis involves direct exhalation into a mass spectrometer, while off-line analysis uses a gas collection device.

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super-SESI Jamil Khirbek super-SESI Jamil Khirbek

Rapid detection of S.aureus and S.pneumoniae by real-time analysis of volatile metabolites

Early detection of pathogenic bacteria is needed for rapid diagnostics allowing adequate and timely treatment of infections. In this study, we show that secondary electrospray ionization–high resolution mass spectrometry (SESI-HRMS) can be used as a diagnostic tool for rapid detection of bacterial infections as a supportive system for current state-of-the-art diagnostics.

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super-SESI Jamil Khirbek super-SESI Jamil Khirbek

SESI-HRMS job opening at Diagnose Eary in the Bay Area

We are thrilled to announce a fantastic job opening at Diagnose Early (www.diagnoseearly.com), a pioneer in advanced technological research. Thanks to recent strategic investments, including the acquisition of several state-of-the-art SUPER SESI - Orbitrap breath analysis machines, DE is at the forefront of biomarker identification research.

www.fossiliontech

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super-SESI Jamil Khirbek super-SESI Jamil Khirbek

Analysis of Volatile Compounds in Garlic, Onion, and Ramsons using SUPER SESI-HRMS

In this study, SUPER SESI-Orbitrap MS was used to analyze the time-resolved gas-phase volatile organic compounds (VOCs) of garlic, ramsons, and onion.

The aim of this study was to address the difficulties of characterizing heat-labile sulfur molecules from various Allium spp. In this, we will delve into the analytical method SUPER SESI-HRMS used in this study and its applications in the analysis of volatile compounds in garlic, onion, and ramsons.

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super-SESI Jamil Khirbek super-SESI Jamil Khirbek

Drug Pharmacokinetics Determined by Real-Time Analysis of Mouse Breath

SUPER SESI-HRMS was used to non-invasively and in real-time monitor the pharmacokinetics of ketamine, propofol, and valproic acid, along with their metabolites in mice. This approach allowed for obtaining real-time pharmacokinetic curves without the need to sacrifice the animals, representing a significant advance in terms of animal welfare and time and cost savings. 

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4th European Single Cell Proteomics (ESCP) Conference

A couple of weeks ago, my colleague Jamil from Fossiliontech attended the Single Cell Proteomics meeting (ESCP, Vienna 2023) and I want to share his notes with you.

I hope this summary will be useful for you :)

Single Cell Analysis: Why?

This technique is essential for understanding cell variability and how it can be applied in diagnostics, personalized therapies, and medical advances.

What technical Challenges need to be addressed?:

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super-SESI Jamil Khirbek super-SESI Jamil Khirbek

FossilionTech in Paris: In Vitro and In Vivo Analyses of VOCs in Food Demo at ThermoFisher Laboratories

A few days ago, we attended a demonstration organized by FossilionTech in the laboratories of Thermo Fisher Scientific in Paris. The performance of the SUPER SESI X-Orbitrap Exploris 120 in the in vitro and in vivo analysis of volatile organic compounds (VOCs) present in food was showcased. The primary goal of this event was to demonstrate the ability of SUPER SESI X-ORBITRAP MS to detect and monitor Volatile Organic Compounds (VOCs) in food, emphasizing the importance of incorporating this technology into food production processes for a deeper understanding of the aromas and flavors of food. Additionally, it highlights the significant improvements in food safety that can be achieved through the adoption of this technology.

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Janeiro-na-Madeira Winter Summer School, 2023 JANUARY 9th to 13th

To start the new year, our CEO Guillermo Vidal will participate in the MS Winter-Summer School in Funchal, Madeira as invited speaker!


Guillermo’s talk will be on the 9th of January as part of the Single Cell proteomics, ultra-sensitive mass spectrometry session:
Revisiting the fundamentals of Electrospray ionization, from art to technology. 

Please join us on J-n-M in person or online! https://jnm-2023.mozellosite.com/

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How to LOTUS, extend the life of your emitter

The new LOTUS emitters improve protein ID and reproducibility with a hydrophobic coating that stabilizes the meniscus.
This application note shows how to extend the lifespan of your LOTUS emitters.

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New Sharp Singularity LOTUS emitters

The new Sharp Singularity LOTUS emitters improve protein ID and reproducibility. It uses the LOTUS effect. This is accomplished by custom design with an hydrophobic coating.

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Meet SESI #2

After learning the basics about SESI in our first post of the "Meet SESI" series, let's go deeper into it.

One of the main advantages of SESI is that it is an extremely soft ionization technique. There are no high-energy ions present at any point in the ionizer. But… why is this so important?

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Meet SESI #1

We are back with our little educational series, which is becoming a thing in FIT! We enjoy doing it, and so we hope you do while reading!

Now it is the turn of SESI, the core of our company. So, why don't we start with the beginning?

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