ionization techniques

Things you didn't know about SESI and ESI (Electro-Spray ionization)

Things you didn't know about SESI and ESI (Electro-Spray ionization)

SESI and ESI (Electro-Spary Ionization) have been linked since the initial development of ESI. Fenn and colleagues already noted that gas-phase species in the counterflow gas were also ionized by the spray. Still today, the routine calibration of mass spectral data relies on ubiquitous plasticizes and other contaminants (i.e. polydimethylcyclosiloxanes, phthalates) that are ionized in regular ESI via Secondary Electrospray Ionization mechanisms.

Differences between SESI and APCI ambient ionization techniques

Differences between SESI and APCI ambient ionization techniques

In the equilibrium, both Secondary Electro Spray Ionization (SESI) and Atmospheric Pressure Chemical Ionization (APCI) generate charged water clusters that act as charging agents. What are the differences bewtween these ionization techniques?