Prof. Jiangjiang Zhu and colleagues develop metabolomics techniques based on Super SESI-Orbitrap to study lung and colorectal cancer, intestinal bacteria and their influence on cancer.
SESI and ESI (Electro-Spary Ionization) have been linked since the initial development of ESI. Fenn and colleagues already noted that gas-phase species in the counterflow gas were also ionized by the spray. Still today, the routine calibration of mass spectral data relies on ubiquitous plasticizes and other contaminants (i.e. polydimethylcyclosiloxanes, phthalates) that are ionized in regular ESI via Secondary Electrospray Ionization mechanisms.