If you are working in metabolomics, pharmacokinetics, biomarker identification, VOC analysis, or other related topic, we would like to invite you to our booth and discuss about how we can help or cooperate with you.
We are proud that Jinan University is now using SUPER SESI for breath analysis and environmental analysis.
We hope this new Super SESI Exhalion coupled with the Orbitrap Mass Spectrometer Q Exactive, will allow the IMSAE researchers to focus on their scientific findings, while taking consistency and performance for granted.
SESI and ESI (Electro-Spary Ionization) have been linked since the initial development of ESI. Fenn and colleagues already noted that gas-phase species in the counterflow gas were also ionized by the spray. Still today, the routine calibration of mass spectral data relies on ubiquitous plasticizes and other contaminants (i.e. polydimethylcyclosiloxanes, phthalates) that are ionized in regular ESI via Secondary Electrospray Ionization mechanisms.
The ETH Zurich (Switzerland) has recently completed the acquisition and installation process of a new SUPER SESI unit for a Thermo Fisher Scientific Orbitrap mass spectrometer, that will help in different fields of the research conducted at this institution related to metabolomic studies.
Rising the humidity level of the gas introduced through the sample line accelerates the charge transfer reaction rate in Secondary Electrospray Ionization (SESI). It is hypothesized that larger clusters transfer their charge more efficiently than smaller clusters or even bare ions.
As you probably already know, current VOC MS analyzers can detect high volatile species, even when they are present in very low concentrations. For instance, in 2009 P. Spanel and D. Smith measured the concentration of ammonia, acetone, methanol, ethanol, and isoprene in human breath using Selected Ion Flow Tube Mass Spectrometry (SIFT-MS)  .
In the equilibrium, both Secondary Electro Spray Ionization (SESI) and Atmospheric Pressure Chemical Ionization (APCI) generate charged water clusters that act as charging agents. What are the differences bewtween these ionization techniques?